Explanation and Elaboration of the ARRIVE Guidelines 2.0—Reporting Animal Research and In Vivo Experiments (Ⅱ)
10.12300/j.issn.1674-5817.2023.042
- VernacularTitle:《动物研究：体内实验报告》即ARRIVE 2.0指南的解释和阐述（二）
- Author:
Guoyuan CHEN
1
;
Xiao LU
2
;
Yu BAI
3
;
Lingzhi YU
4
;
Ying QIAO
3
;
Jian WANG
5
;
Jin LU
5
;
Xiaoyu LIU
6
;
Xuancheng LU
7
;
Jing GAO
8
;
Yao LI
5
;
Wanyong PANG
9
Author Information
1. Animal Core Facility, Center for Excellence in Molecular Cell Science, Chinese Academy of Science, Shanghai 200031, China
2. Dizal Pharmaceuticals Co., Ltd., Shanghai 201203, China
3. Novo Nordisk Research Centre China, Beijing 102206, China
4. Shanghai Laboratory Animal Research Center, Shanghai 201203, China
5. Department of Laboratory Animal Science, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China
6. National Institute for Occupational Health and Poison Control, Chinese Center for Disease Control and Prevention, Beijing 100050, China
7. Laboratory Animal Center, Chinese Center for Disease Control and Prevention, Beijing 102206, China
8. Clinical Research Institute, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China
9. Translational in Vivo Model Research Platform, Sanofi G&D, Beijing 100022, China
- Publication Type:Journal Article
- Keywords:
Animal experiment;
ARRIVE 2.0 guidelines;
ARRIVE Essential 10;
Randomization;
Blinding;
Outcome measurement;
Statistical methods
- From:
Laboratory Animal and Comparative Medicine
2023;43(3):323-331
- CountryChina
- Language:Chinese
-
Abstract:
Improving the reproducibility of biomedical research results remains a major challenge. Transparent and accurate reporting of progress can help readers evaluate the reliability of research results and further explore an experiment by repeating or building upon its findings. The ARRIVE 2.0 guidelines, released in 2019 by the UK National Centre for the Replacement, Refinement, and Reduction of Animals in Research (NC3Rs), provide a checklist applicable to any in vivo animal research report. These guidelines aim to improve the standardization of experimental design, implementation, and reporting, as well as the reliability, repeatability, and clinical translatability of animal experimental results. The use of the ARRIVE 2.0 guidelines not only enriches the details of animal experimental research reports, ensuring that information on animal experimental results is fully evaluated and utilized, but also enables readers to understand the content expressed by the author accurately and clearly, promoting the transparency and integrity of the fundamental research review process. At present, the ARRIVE 2.0 guidelines have been widely adopted by international biomedical journals. This article is the second part of the Chinese translation of the complete interpretation of the ARRIVE 2.0 guidelines published in PLoS Biology in 2020 (original text can be found at https://arriveguidelines.org) and based on the best practices for following the ARRIVE 2.0 guidelines in international journals. This part includes Items 4-7 of "ARRIVE Essential 10" in the ARRIVE 2.0 guidelines: "Randomization", "Blinding", "Outcome Measurement", and "Statistical Methods". Our Chinese translated version aims to promote the full understanding and use of the ARRIVE 2.0 guidelines by domestic researchers, enhancing the standardization of experimental animal research and reporting, and promoting the high-quality development of experimental animal technology and comparative medicine research in China.
