Advances and Applications in Animal Models of Neuroblastoma
10.12300/j.issn.1674-5817.2022.194
- VernacularTitle:神经母细胞瘤动物模型研究进展与应用
- Author:
Zhigang TAN
1
;
Jinxin LIU
1
;
Chuya ZHENG
1
;
Wenfeng LIAO
1
;
Luping FENG
1
;
Hongli PENG
1
;
Xiu YAN
2
;
Zhenjian ZHUO
1
Author Information
1. Laboratory Animal Center, Peking University Shenzhen Graduate School, Shenzhen 518055, China
2. Foshan University, Foshan 528200, China
- Publication Type:Journal Article
- Keywords:
Neuroblastoma;
Animal model;
Mice;
Chick embryo chorioallantoic-membrane;
Zebrafish
- From:
Laboratory Animal and Comparative Medicine
2023;43(3):288-296
- CountryChina
- Language:Chinese
-
Abstract:
Neuroblastoma (NB) is one of the most common malignant solid tumors in children, ranks fourth in the incidence of pediatric tumors, and accounts for 15% of pediatric tumor deaths in children in China. Despite the development of new treatment options, the prognosis for high-risk patients is still poor. An animal model that can replicate the tumorigenesis of NB is an important tool for the prevention and treatment of NB. However, there are currently no animal models that can simulate all features of human NB. To provide a reference for the construction of animal models and treatment of NB, this article introduced several animal models of NB that have been extensively researched: the mouse, chick embryo chorioallantoic membrane, and zebrafish models. At the same time, it elaborated on the species, construction methods, characteristics, advantages and disadvantages, and research progress in NB.
