Research Progress on Establishing and Evaluation of Acne Animal Models
10.12300/j.issn.1674-5817.2023.021
- VernacularTitle:痤疮动物模型建立及评价研究进展
- Author:
Rui ZHANG
1
;
Meiyu LÜ
1
;
Jianjun ZHANG
1
;
Jinlian LIU
1
;
Yan CHEN
2
;
Zhiqiang HUANG
2
;
Yao LIU
2
;
Lanhua ZHOU
3
Author Information
1. School of Traditional Chinese Medicine, Beijing University of Chinese Medicine, Beijing 102488, China
2. School of Chinese Materia Medica, Beijing University of Chinese Medicine, Beijing 102488, China
3. Department of dermatology, Beijing Jingcheng Skin Hospital, Beijing 100192, China
- Publication Type:Journal Article
- Keywords:
Acne;
Animal models;
Research progress
- From:
Laboratory Animal and Comparative Medicine
2023;43(4):398-405
- CountryChina
- Language:Chinese
-
Abstract:
According to understanding of the pathogenesis of acne, scholars have established animal models of acne inflammation, animal models of grafting human skin acne, and natural acne animal models. The acne inflammation model is mainly induced by bacterial infection, chemical drug application, and foreign matter injection. Natural acne animal models include animals that some are sensitivity to hormones and some have clinical symptoms of acne. It is necessary to select appropriate model animals and replicate model methods for the development of acne intervention products with different degrees and mechanisms. At present, there are only human evaluation standards of acne health functions in China, but no animal evaluation standards, which has affected the in-depth study of the pathogenesis of acne as well as the research and development progress of acne products. This article summarizes the conditions for the occurrence of acne, the characteristics of human skin, the bidirectional effect of Cutibacterium acnes on human skin, acne animal models, and commonly used observation and evaluation indicators, providing the reference for studying the pathogenesis of acne, promoting acne treatment and health care, and developing treatment products.
