Progress in Establishment and Application of Laboratory Animal Models Related to Development of Male Infertility Drugs
10.12300/j.issn.1674-5817.2023.120
- VernacularTitle:雄性不育药物研发相关实验动物模型建立和应用进展
- Author:
Shuwu XIE
1
;
Ruling SHEN
1
;
Jinxing LIN
1
;
Chun FAN
1
Author Information
1. Shanghai Laboratory Animal Research Center, Shanghai 201203, China
- Publication Type:Review
- Keywords:
Male infertility;
Drug development;
Laboratory animal models
- From:
Laboratory Animal and Comparative Medicine
2023;43(5):504-511
- CountryChina
- Language:Chinese
-
Abstract:
As the incidence of male infertility has been increasing during recent years, it is urgent to reveal the pathogenesis of male infertility, as well as to develop the new drugs for treatment of male infertility, in order to solve the declining birth rate and aging problems. The construction and application of male infertile animal models is critical for drug development, which plays an important role in accurately evaluating the efficacy and mechanism of infertility treatment. A suitable infertility model not only can reduce the repeated drug efficacy evaluations, reduce animal usage and the cost of new drug development, but also has important reference value for subsequent clinical trial research. Male infertility laboratory animal models can be constructed through chemical, physical, endocrine, environmental estrogen, gene modification, and immune methods. This article mainly introduces the existing male infertility animal models available for drug development, and briefly introduces the application progress of each model to provide reference for the male infertility drug researchers.
