A Hydroxyurea-induced Leg Ulcer.
- Author:
Seon Wook HWANG
1
;
Soon Kwon HONG
;
Sang Hyun KIM
;
Jong Keun SEO
;
Deborah LEE
;
Ho Suk SUNG
Author Information
- Publication Type:Case Report
- Keywords: Cutaneous side effects; Hydroxyurea; Leg ulcer
- MeSH: Aged; Female; Humans; Hydroxyurea; Hyperpigmentation; Korea; Leg; Leg Ulcer; Nails; Robenidine; Thrombocytosis; Ulcer
- From:Annals of Dermatology 2009;21(1):39-41
- CountryRepublic of Korea
- Language:English
- Abstract: Hydroxyurea is a cytostatic agent that has recently become the drug of choice in the treatment of various myeloproliferative diseases. The cutaneous side effects of hydroxyurea include xerosis, hyperpigmentation, nail discoloration, and scaling. Leg ulcers have only rarely been reported in association with hydroxyurea treatment. A 75-year-old woman presented with leg ulcers, nail discoloration, and xerosis. The leg ulcers were refractory to conventional treatment. She had been taking oral hydroxyurea since being diagnosed with essential thrombocytosis in 2002. Hence, we suspected hydroxyurea-induced leg ulcers and discontinued her hydroxyurea treatment; the ulcers gradually healed thereafter. We present a rare case of hydroxyurea-induced leg ulcers in Korea.
