Study on the mechanism of anti-inflammatory and hepatoprotective effects of Shuganning injection based on network pharmacology
10.12206/j.issn.2097-2024.202204049
- VernacularTitle:基于网络药理学对舒肝宁注射液抗炎保肝作用的机制研究
- Author:
Bao XIN
1
;
Fangyuan XIE
1
;
Chen YAO
1
;
Jiyun GE
1
;
Jing LIU
1
;
Jing ZHANG
1
;
Hong MIAO
1
;
Tingting HUANG
1
;
Yufeng HUANG
1
Author Information
1. Department of Pharmacy, the Third Affiliated Hospital of Naval Medical University, Shanghai 200438, China.
- Keywords:
Shuganning injection;
anti-inflammatory effect;
network pharmacology;
molecular mechanism
- From:
Journal of Pharmaceutical Practice and Service
2022;40(6):563-570
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the anti-inflammatory and hepatoprotective mechanism of Shuganning injection through establishing the active ingredients-targets network and protein interactions network. Methods The main active ingredients of Artemisiae scopariae, Fructus gardenia, Radix scutellariae, Radix isatidis and Ganoderma in Shuganning injection were obtained by TCMSP; GeneCards and OMIM were used to screen the hepatitis-related targets among the corresponding targets of the active ingredient of Shuganning injection; The Cytoscape software was used to construct the active ingredient-targets network of Shuganning injection. The protein interactions network was constructed using the String database and Cytoscape software. The GO and KEGG pathways involved in the targets were analyzed by DAVID database. Results The results showed that 20 active ingredients and 83 targets of Shuganning injection were involved. GO analysis showed that Shuganning injection mainly affected the regulation of cellular processes and biological processes, as well as the response to chemical stimulation and stress. KEGG pathway analysis showed that the targets of the anti-inflammatory and hepatoprotective effect of Shuganning injection mainly involved in signaling pathways such as TNF, IL-17, and MAPK. Conclusion The anti-inflammatory and hepatoprotective effect of Shuganning injection have the characteristics of multiple components, multiple targets and multiple pathways, which may play a role by regulating pathways such as TNF、IL-17 and MAPK .
