Study on quality standards of volatile oil of Chunyang Zhengqi capsules

VernacularTitle:纯阳正气胶囊挥发油的质量标准研究
Author: Feixue WEI ¹ ; Xiaoju LI ¹ ; Sisi XIONG ¹ ; Yunfang LIAO ¹ ; Min CHEN ¹
Author Information

1. Eight Plus One Pharmaceutical Co., Ltd, Guilin 541000, China.
Keywords: Chunyang Zhengqi capsules; quality standards; characteristic atlas; GC; assay; volatile oil
From: Journal of Pharmaceutical Practice and Service 2022;40(6):557-562
CountryChina
Language:Chinese
Abstract: Objective To establish a quality control system of volatile oil of Chunyang Zhengqi capsules. Methods The chromatogram of volatile oil was established by GC method, and the contents of cinnamaldehyde and eugenol were determined. Results In 15 batches of samples, 19 common peaks were identified, and 9 characteristic peaks were selected to establish the characteristic spectrum. The linear ranges of cinnamaldehyde and eugenol were 0.522 - 1.565 mg/ml (r=0.9994) and 3.038 - 9.115 mg/ml (r=0.9997), respectively. The average recoveries were 97.1% and 97.3%, with RSD of 1.5% and 1.4%, respectively. Conclusion The established GC characteristic map and content determination method could control the quality of essential oil in Chunyang Zhengqi capsules qualitatively and quantitatively. The method is accurate and feasible which could be used as the quality control method of essential oil in Chunyang Zhengqi capsules.