Analysis of volatile organic compounds in urine of diabetic patients comorbid with depression
10.12206/j.issn.2097-2024.202206045
- VernacularTitle:糖尿病共病抑郁患者尿液挥发性有机化合物分析
- Author:
Zhijun GUO
1
;
Xuyin DING
2
;
Zhuman LI
1
;
Yunpeng MA
1
;
Yan WANG
1
;
Xuemei YU
1
;
Min ZHANG
2
;
Feng XU
1
Author Information
1. Sixth People’s Hospital South Campus, Shanghai Jiaotong University, Shanghai 201400, China.
2. School of Chemistry and Molecular Engineering, East China Normal University, Shanghai 200241, China.
- Keywords:
diabetic;
depression;
urine;
volatile organic compounds
- From:
Journal of Pharmaceutical Practice and Service
2022;40(6):540-545
- CountryChina
- Language:Chinese
-
Abstract:
Objective To compare the difference of volatile organic compounds (VOCs) in the urine of diabetic patients comorbid with or without depression. Methods Patients with type 2 diabetes who met the diagnostic criteria of prevention and treatment guidelines and were treated in inpatient department of Sixth People’s Hospital South Campus, Shanghai Jiaotong University, from November 2019 to November 2020 were included in the study. Depression screening was performed using PHQ9 scale. According to the scores, the patients were divided into two groups: diabetic patient group and diabetic patient comorbidity depression group. The morning urine was collected and VOCs in urine were detected using a miniature gas tester. Results A total of 161 patients with diabetes mellitus, including 141 patients in the diabetic group and 20 patients in the diabetic comorbidity depression group. The results indicated that the sensitivity, specificity and accuracy of the method are 80%, 98% and 92.8% respectively. There were differences in urine volatile organic compounds between the two groups. Conclusions Compared with diabetic patients, the composition of volatile organic compounds in urine may change after diabetic comorbidity depression, which can provide experimental reference for early clinical diagnosis of depression.
