Study on the secondary metabolites from a polar marine sponge associated actinomyces Streptomyces sp. LHW11-07
10.12206/j.issn.2097-2024.202206081
- VernacularTitle:极地海绵共附生放线菌Streptomyces sp. LHW11-07次生代谢产物研究
- Author:
Jingrong LU
1
;
Yawei LIU
2
;
Ying DAI
3
;
Houwen LIN
1
;
Fan YANG
1
Author Information
1. Department of Pharmacy, Renji Hospital Affiliated to School of Medicine, Shanghai Jiaotong University, Shanghai 200127, China.
2. School of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University, Shenyang 110016, China.
3. College of Food Science and Technology, Shanghai Ocean University, Shanghai 201306, China.
- Keywords:
polar region;
sponge;
actinomyces;
secondary metabolite
- From:
Journal of Pharmaceutical Practice and Service
2022;40(6):499-504
- CountryChina
- Language:Chinese
-
Abstract:
Objective In order to obtain small molecule compounds with novel structure and good biological activity, the secondary metabolites of polar sponge-symbiotic Streptomyces sp. LHW11-07 were studied. Methods The fermentation product of Streptomyces sp. LHW11-07 was isolated and purified by gel column chromatography, silica gel column chromatography, reversed-phase medium pressure column chromatography and high performance liquid chromatography. The structures of the monomeric compound were identified by modern spectroscopic methods such as mass spectrometry, nuclear magnetic resonance and related literature reports. Results A total of nine compounds were isolated from the fermentation of this strain, which were cyclo-(L-Tyr-L-Trp) (1), cyclo-(L-Trp-L-Ser) (2), cyclo-(D-Tyr-D-Pro) (3), cyclo-(L-Tyr-L-Phe) (4), cyclo-(L-Tyr-L-Leu) (5), albaflavenol B (6), β-adenosine (7), N-formylantimyic acid methyl ester (8) and conglobatin A (9). Conclusion Compounds 1 and 2 were isolated from Streptomyces sp. for the first time.
