The latest research progress of α7 nicotinic acetylcholine receptor in cholinergic anti-inflammatory pathway
10.12206/j.issn.2097-2024.202204037
- VernacularTitle:胆碱能抗炎通路α7烟碱型乙酰胆碱受体的最新研究进展
- Author:
Huimin ZHANG
1
;
Kefa XIANG
1
;
Xiaofei SHI
1
;
Zhen QIN
1
;
Xia LIU
1
Author Information
1. Department of Clinical Pharmacy , School of Pharmacy , Naval Medical University , Shanghai 200433 , China.
- Keywords:
α7nAChR;
cholinergic anti-inflammatory pathway;
energy metabolism;
mitochondria;
neurodegenerative diseases
- From:
Journal of Pharmaceutical Practice and Service
2022;40(6):485-493
- CountryChina
- Language:Chinese
-
Abstract:
α7 nicotinic acetylcholine receptor (α7nAChR) belongs to nicotinic acetylcholine receptors (nAChRs), which is the key receptor in cholinergic anti-inflammatory pathway and plays an important role in the neural regulation of immune system. Recent studies have found that α7nAChR is also involved in the regulation of various physiological and pathological processes other than immunity, such as non-alcoholic fatty liver, angiogenesis, heart protection, etc. In addition, α7nAChR is closely related to energy metabolism in neurodegenerative diseases. This article reviews the role of α7nAChR in treating inflammation and improving energy metabolism, and the new direction of α7nAChR involved in therapy.
