Research progress on hepatic macrophages and liver fibrosis
10.12206/j.issn.2097-2024.202209030
- VernacularTitle:肝巨噬细胞与肝纤维化研究进展
- Author:
Haiyan JIANG
1
;
Fangfang ZHONG
1
;
Junping ZHANG
1
Author Information
1. School of Pharmacy, FuJian University of Traditional Chinese Medicine, Fuzhou 350100, China.
- Keywords:
hepatic macrophages;
liver fibrosis;
phenotypic switch
- From:
Journal of Pharmaceutical Practice and Service
2024;42(4):135-140
- CountryChina
- Language:Chinese
-
Abstract:
Liver fibrosis is a repair response to chronic liver injury caused by various etiologies. Its continuous progression can develop into liver cirrhosis or even hepatocellular carcinoma, eventually leading to liver failure. Currently, there is no effective treatment for liver fibrosis. Hepatic macrophages play a key role in intrahepatic inflammatory response, progression and resolution of fibrosis, and have emerged as an important therapeutic target for anti-hepatic fibrosis. The function of hepatic macrophages in the process of liver fibrosis was mainly reviewed and the mode of action of hepatic macrophages from various aspects was discussed to provide ideas for the treatment of liver fibrosis.
