Establishment of mitral regurgitation model by a transapical artificial chordae tendineae implantation device in swines

Lishan Zhong; Yanchen Yang; Yanying Huang; Zhenzhong Wang; Shuo Xiao; Dou Fang; Qiuji Wang; Qizong Xie; Xusheng Zhang; Haiming WU; Huanlei Huang

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Establishment of mitral regurgitation model by a transapical artificial chordae tendineae implantation device in swines

VernacularTitle:采用经心尖人工腱索植入装置建立二尖瓣反流动物模型
Author: Lishan ZHONG ¹ ; Yanchen YANG ² ; Yanying HUANG ³ ; Zhenzhong WANG ¹ ; Shuo XIAO ⁴ ; Dou FANG ⁵ ; Qiuji WANG ⁶ ; Qizong XIE ⁷ ; Xusheng ZHANG ⁷ ; Haiming WU ⁷ ; Huanlei HUANG ^{8
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Author Information

1. Guangdong Cardiovascular Institute, Guangdong Provincial People s Hospital (Guangdong Academy of Medical Sciences), Southern Medical University, Guangzhou, 510080, P. R. China
2. The First People s Hospital of Foshan, Foshan, 528000, Guangdong, P. R. China
3. 1. Guangdong Cardiovascular Institute, Guangdong Provincial People s Hospital (Guangdong Academy of Medical Sciences), Southern Medical University, Guangzhou, 510080, P. R. China 3. Guangdong Cardiovascular Institute, Guangdong Provincial People s Hospital, Guangdong Academy of Medical Sciences, Guangzhou, 510080, P. R. China
4. 1. Guangdong Cardiovascular Institute, Guangdong Provincial People s Hospital (Guangdong Academy of Medical Sciences), Southern Medical University, Guangzhou, 510080, P. R. China 4. South China University of Technology, Guangzhou, 510641, P. R. China
5. 1. Guangdong Cardiovascular Institute, Guangdong Provincial People s Hospital (Guangdong Academy of Medical Sciences), Southern Medical University, Guangzhou, 510080, P. R. China 5. Southern Medical University, Guangzhou, 510515, P. R. China
6. Department of Cardiac Surgery, Guangdong Provincial People s Hospital (Guangdong Academy of Medical Sciences), Southern Medical University, Guangzhou, 510080, P. R. China
7. Hanxin Medical Technology (Shenzhen) Co., Ltd., Shenzhen, 518109, P. R. China
8. 1. Guangdong Cardiovascular Institute, Guangdong Provincial People s Hospital (Guangdong Academy of Medical Sciences), Southern Medical University, Guangzhou, 510080, P. R. China 6. Department of Cardiac Surgery, Guangdong Provincial People'
9. s Hospital (Guangdong Academy of Medical Sciences), Southern Medical University, Guangzhou, 510080, P. R. China
Publication Type:Journal Article
Keywords: Mitral regurgitation; animal model; transapical; artificial chordae tendineae implantation device
From: Chinese Journal of Clinical Thoracic and Cardiovascular Surgery 2024;31(04):570-575
CountryChina
Language:Chinese
Abstract: Objective To research the procedure for creating an animal model of mitral regurgitation by implanting a device through the apical artificial chordae tendineae, and to assess the stability and dependability of the device. Methods Twelve large white swines were employed in the experiments. Through a tiny hole in the apex of the heart, the artificial chordae tendineae of the mitral valve was inserted under the guidance of transcardiac ultrasonography. Before, immediately after, and one and three months after surgery, cardiac ultrasonography signs were noted. Results All models were successfully established. During the operation and the follow-up, no swines died. Immediately after surgery, the mitral valve experienced moderate regurgitation. Compared with preoperation, there was a variable increase in the amount of regurgitation and the values of heart diameters at a 3-month follow-up (P<0.05). Conclusion In off-pump, the technique of pulling the mitral valve leaflets with chordae tendineae implanted transapically under ultrasound guidance can stably and consistently create an animal model of mitral regurgitation.