Antibody levels against varicella-zoster virus in healthy individuals aged 1 to 30 years in Songjiang District of Shanghai in 2022
10.19428/j.cnki.sjpm.2024.23579
- VernacularTitle:2022年上海市松江区1~30岁健康人群水痘-带状疱疹病毒抗体水平分析
- Author:
Wenhua CHEN
1
;
Jinhua SHEN
1
;
Qi ZHU
1
;
Hongcen YAO
1
;
Hongmei LU
1
Author Information
1. Shanghai Songjiang District Center for Diseases Control and Prevention， Shanghai 201620， China
- Publication Type:Journal Article
- Keywords:
varicella-zoster virus;
varicella vaccine;
IgG antibody;
antibody positive rate
- From:
Shanghai Journal of Preventive Medicine
2024;36(4):337-341
- CountryChina
- Language:Chinese
-
Abstract:
ObjectiveTo determine the antibody levels of varicella-zoster virus （VZV） in healthy individuals aged 1 to 30 years in Songjiang District of Shanghai， and to provide evidence for further development of varicella immunization strategies for healthy population. MethodsSix village committees were selected in Songjiang District through multi-stage stratified random sampling method from July to September 2022. Healthy individuals aged 1 to 30 years old in these villages were recruited and 3‒5 mL of venous blood was collected. Anti-VZV IgG antibody was tested by ELISA. Positive rate of anti-VZV IgG antibody and geometric mean concentration （GMC） were determined. ResultsA total of 315 healthy individuals aged （10.97±8.38） years were included in this study， of which 165 were males aged （11.00±8.52） years and 150 were females aged （10.96±8.25） years. Blood samples were collected and tested for anti-VZV IgG antibody， with the overall positive rate of 55.24% （174/315）. The GMC was calculated to be 99.73 mIU·mL-1， with the GMC in those tested positive for anti-VZV IgG antibody of 413.11 mIU·mL-1. The positive rate of anti-VZV IgG antibody and GMCs across age groups ranged between 13.33%‒86.67% and 16.36‒355.14 mIU·mL-1， respectively. The highest GMC was found in the group of 20‒30 years old （355.14 mIU·mL-1）， followed by 132.41 mIU·mL-1 in the group of 5‒ years old and 138.12 mIU·mL-1 in the group of 15‒ years old. Moreover， the positive rate was 38.47% in the group with 1-dose varicella vaccine and 63.49% in the group with 2 doses， while the GMC were 53.28 mIU·mL-1 and 130.79 mIU·mL-1 in these two groups， respectively. Multivariable analysis revealed that occupation was a risk factor associated with anti-VZV IgG antibody （OR=2.540）. Stratified analysis by varicella immunization history showed that among 2-dose vaccination group， time interval since the last dose was a protective factor （OR=0.315）. ConclusionsThe overall positive rate of anti-VZV IgG antibody in healthy population in Songjiang District of Shanghai remains low. The 2-dose varicella vaccination should be strengthened to improve the coverage in susceptible population.
