Pharmacological Research Progress for Anti-tumor Effect of Kaempferol
10.19378/j.issn.1003-9783.2024.03.018
- VernacularTitle:山柰酚抗肿瘤作用的药理研究进展
- Author:
Zhiming ZHU
1
;
Juanjuan WANG
;
Sumei WANG
;
Qichun ZHOU
Author Information
1. 广州中医药大学第二临床医学院药剂科,广东 广州 510120
- Keywords:
kaempferol;
anti-tumor;
mechanism;
apoptosis;
autophagy
- From:
Traditional Chinese Drug Research & Clinical Pharmacology
2024;35(3):445-452
- CountryChina
- Language:Chinese
-
Abstract:
Kaempferol,a natural flavonoid compound,can be extracted from various traditional Chinese medicine,fruits and vegetables.It possesses effective physiological activity,low toxicity and low side effects.It has been revealed by the research results that kaempferol exhibits obvious preventive and inhibitory effects on many common cancers,such as colon cancer,breast cancer,leukemia,etc..The anti-tumor effects are mainly exerted by blocking cell cycle,inhibiting invasion and migration,inducing cell apoptosis and autophagy,and inhibiting aerobic glycolysis of tumors.Meanwhile,the combination of kaempferol and many drugs can produce synergistic anti-tumor and sensitizing effects.The nano-preparation of kaempferol has significant curative effect in the treatment of tumor,which indicates that kaempferol has a good clinical application prospect.In this work,the pharmacological research progress for anti-tumor effect of kaempferol in recent years was reviewed.This article aims to provide theoretical basis and research ideas for further research of kaempferol.
