Analysis of Animal Models of Post-infectious Irritable Bowel Syndrome Based on Characteristics of Clinical Symptoms of Traditional Chinese and Western Medicine
10.19378/j.issn.1003-9783.2024.01.011
- VernacularTitle:基于中西医临床特点的感染后肠易激综合征动物模型分析
- Author:
Lu'an XIE
1
;
Yangyu ZHANG
;
Xiaoxia CHEN
;
Zhendong PAN
;
Yiling YANG
;
Shi HUANG
Author Information
1. 广西中医药大学,广西 南宁 530001
- Keywords:
Post-infectious irritable bowel syndrome(PI-IBS);
disease-syndrome combination;
animal model;
clinical features of Chinese and western medicine
- From:
Traditional Chinese Drug Research & Clinical Pharmacology
2024;35(1):92-102
- CountryChina
- Language:Chinese
-
Abstract:
Objective This paper summarizes and evaluates the existing animal models of Post-infectious irritable bowel syndrome(PI-IBS)based on the clinical diagnostic criteria and symptom characteristics of PI-IBS in Chinese and western medicine.The goal of this study is to seek out animal models with a high degree of clinical agreement between Chinese and western medicine,and to provide an accurate animal model for the prevention and treatment of PI-IBS in traditional Chinese medicine.Methods The animal strains,modelling methods,and mechanisms of the existing PI-IBS animal models were summarized based on the clinical diagnostic features and symptomatology of PI-IBS,as well as the degree of match was evaluated and the strengths and weaknesses of the preparation of animal models were analyzed,by reviewing the articles related to PI-IBS animal experiments and the preparation of animal models.Results A thorough analysis discovered that Campylobacter jejuni infection model,Trichinella infection model,and liver depression and spleen deficiency syndrome in models of disease and symptom combination showed a comparatively high level of clinical agreement between Chinese and western medicine.Conclusion The existing PI-IBS models had the high degree of coincidence with western medicine,Chinese medicine four diagnoses and syndrome are generally less embodied and collected in the modeling process.The primary symptoms in Chinese medicine diagnosis are primarily based on the observation of animal apparent behaviors,while the observation of the sub-syndrome manifestations is relatively less,which results in failure of judgment of TCM syndrome types.Therefore,it is still necessary to further standardize the criteria for evaluating symptoms and the techniques for identifying disease-syndrome combination animal models.PI-IBS model with the syndrome-clinical characteristics in Chinese and western medicine has significant application value and prospects in the future.The multifactorial composite method of western medicine pathological injury+Chinese medicine etiological stimulation can establish a PI-IBS model with a higher degree of coincidence,which can provide theoretical support for the study of the pathogenesis of PI-IBS,the difference of syndrome,and the prevention and treatment with integrative Chinese and western medicine.It is crucial to guide the clinical diagnosis and treatment of PI-IBS.
