Research Progress on Antifibrotic Effect and Molecular Mechanisms of Chemical Components from Astragali Radix
10.19378/j.issn.1003-9783.2023.12.018
- VernacularTitle:黄芪化学成分抗纤维化作用及分子机制研究进展
- Author:
Jiajun WANG
1
;
Shixie XIANG
;
Zhishen XIE
;
Pan WANG
;
Jinxin MIAO
;
Zhenqiang ZHANG
;
Xiaowei ZHANG
;
Jiangyan XU
Author Information
1. 河南中医药大学,河南郑州 450046
- Keywords:
Astragali Radix;
chemical constituents;
antifibrosis;
mechanism of action
- From:
Traditional Chinese Drug Research & Clinical Pharmacology
2023;34(12):1799-1805
- CountryChina
- Language:Chinese
-
Abstract:
Fibrosis refers to the final outcome of damage in multiple-type tissue and the imbalance of tissue repair especially in the process of chronic inflammatory response diseases.Fibrosis can occur in various organ tissues.Its continuous progression may lead to organ dysfunction and failure,which is a huge threat to human health.Traditional Chinese medicine has significant therapeutic effects in preventing and treating fibrosis.Due to its characteristics of multiple components,pathways,and targets,it has become a hot research topic in the field of fibrosis.Astragali Radix,a Chinese medicinal for supplementing qi,is the root of Astragalus membranaceus(Fisch.)Bge.var.mongholicus Hisao or Astragalus membranaceus(Fisch.)Bge.It has the effects of replenishing qi and elevating yang,generating fluid and nourishing blood,expelling toxin and draining pus,astringing sore and promoting granulation.It has found that Astragali Radix contains many chemical components such as polysaccharides,saponins,and flavonoids,which have good anti-inflammatory and antioxidant effects.Astragali Radix can effectively intervene in the fibrosis process of multiple organ tissues such as the heart,kidney,liver,and lung.Therefore,this article reviews the anti-fibrotic effects and mechanisms of Astragali Radix and its chemical components,hoping to provide ideas and references for the development and utilization of Astragali Radix.
