Study on the Effect of Yi'naokang Capsules Combined with Donepezil Hydrochloride Tablets on Patients with Post-stroke Cognitive Impairment
10.19378/j.issn.1003-9783.2023.12.017
- VernacularTitle:益脑康胶囊联合盐酸多奈哌齐片对卒中后认知障碍患者的疗效研究
- Author:
Daiyi CHEN
1
;
Huijuan LIAO
;
Haorong YAN
;
Qiliang LIU
;
Rongjian LIANG
;
Jingbo SUN
Author Information
1. 广州中医药大学第二临床医学院,广东广州 510006
- Keywords:
Yin'aokang Capsules;
Donepezil Hydrochloride Tablets;
cognitive impairment after stroke;
cognitive function;
cerebral white matter lesions;
clinical effect
- From:
Traditional Chinese Drug Research & Clinical Pharmacology
2023;34(12):1793-1798
- CountryChina
- Language:Chinese
-
Abstract:
Objective To observe the clinical effect of Yi'naokang Capsules combined with Donepezil Hydrochloride Tablets in treating post-stroke cognitive impairment(PSCI).Methods 110 patients who met the diagnostic criteria of PSCI in the outpatient department were included.According to the random number table method,the patients were divided into trial group and control group,with 55 cases in each group.Patients in control group were treated with routine western medicine,including the treatment of Donepezil Hydrochloride Tablets and secondary prevention of stroke such as lowering blood pressure,lowering blood lipid,lowering blood glucose and anti-platelet aggregation.The trial group was treated with Yi'naokang Capsules on the basis of the treatment in control group,and both groups were treated for 6 months.Before and after 6 months of treatment,the cognitive function of patients was evaluated by the Montreal Cognitive Assessment(MoCA)scale.The activity of daily living(ADL)scale was used to evaluate the ability of daily living,and the severity of cerebral white matter lesions was evaluated by Fazekas scale,and the adverse reactions were also observed.Results After 6 months of treatment,the total score of the MoCA,the scores of visual space and executive function,attention,delayed recall and the ADL of the two groups were all improved(P＜0.05),and the improvement degree of the trial group was better than that of the control group(P＜0.05).The Fazekas score of the trial group after treatment was no significant difference when compared with that before treatment(P＞0.05),but it increased in the control group after treatment(P＜0.05),and the effect of delaying white matter lesion in the trial group was better than that in the control group(P＜0.05).Conclusion Yi'naokang Capsules combined with Donepezil Hydrochloride Tablets are superior to Donepezil alone in the treatment of PSCI,which can safely and effectively improve the cognitive function and daily living ability of patients,as well as prolong the progress of white matter lesions.
