Biological function and action mechanism of prefoldin 5 and its advancements in malignant tumors

VernacularTitle:前折叠蛋白5的生物学功能与作用机制及其在恶性肿瘤中的研究进展
Author: Xiaoren ZHU ¹ ; Yuanyuan LIU ; Jianzhuo JIANG ; Minbin CHEN
Author Information

1. 江苏大学附属昆山医院肿瘤科，昆山　215300
Keywords: Neoplasms; Prefoldin; Biological phenomena; Proto-oncogene proteins c-myc; Molecular targeted therapy
From: Cancer Research and Clinic 2024;36(3):237-240
CountryChina
Language:Chinese
Abstract: Prefoldin (PFDN), a hexameric chaperone complex, is crucial for the correct folding of nascent proteins. PFDN5, a subunit of PFDN, also known as MM-1, plays an essential role in regulating cell migration and senescence. Emerging evidences suggest that PFDN-5 deletion or mutation significantly contributes to the initiation and progression of multiple cancers and the prognosis of patients. In this paper, recent researches on the biological underpinnings of PFDN-5 and its anti-cancer prospect are reviewed, aiming to provide a novel potential therapeutic target for the treatment of malignancies.