Progress of PFKFB3 and PFKFB4 in breast cancer
10.3760/cma.j.cn115355-20221010-00634
- VernacularTitle:PFKFB3和PFKFB4在乳腺癌中的研究进展
- Author:
Haochen WANG
1
;
Shulong JIANG
Author Information
1. 济宁医学院临床医学院，济宁 272000
- Keywords:
Breast neoplasms;
Glycolysis;
Phosphofructokinases;
PFKFB3;
PFKFB4;
Treatment outcome
- From:
Cancer Research and Clinic
2023;35(11):870-874
- CountryChina
- Language:Chinese
-
Abstract:
The incidence of breast cancer has jumped to the first place in malignant tumors, posing a severe threat to women's health. Different from oxidative phosphorylation metabolism of normal cells, breast cancer cells often undergo metabolic reediting characterized by aerobic glycolysis. In the process of initiating aerobic glycolysis, phosphofructokinase-2/fructose bisphosphatase-2 (PFK-2/FBPase-2) family isozymes PFKFB3 and PFKFB4 play key roles and are involved in the growth and proliferation, invasion and migration, autophagy, and drug resistance of breast cancer. This review summarizes the correlation of PFKFB3 and PFKFB4 with breast cancer, aiming to provide a reference for future breast cancer-related research and clinical translation.
