Progress of molecular mechanisms of cell pyroptosis regulating tumor immune microenvironment in hematologic malignancies
10.3760/cma.j.cn115355-20230115-00033
- VernacularTitle:血液系统恶性肿瘤细胞焦亡调控肿瘤免疫微环境分子机制的研究进展
- Author:
Mingxia CHENG
1
;
Yuan FU
;
Qike ZHANG
;
Jin HE
Author Information
1. 甘肃省人民医院血液科，兰州 730030
- Keywords:
Hematologic neoplasms;
Pyroptosis;
Immunity;
Tumor microenvironment;
Gasdermins;
Inflammasome
- From:
Cancer Research and Clinic
2023;35(10):793-797
- CountryChina
- Language:Chinese
-
Abstract:
The relationship between pyroptosis and immune microenvironment and disease has received increasing attention. Pyroptosis plays a dual role in anti-tumor immunotherapy by promoting the release of inflammatory factors, forming the tumor microenvironment and suppressing tumour immunity on the one hand, and inducing the tumour inflammatory response to inhibit the proliferation of tumor cells on the other hand. The relationship between pyroptosis, immune microenvironment and tumors is different in different tissues and genetic backgrounds. This article reviews the molecular mechanisms of pyroptosis and the regulatory role of tumor immune microenvironment in hematologic malignancies, with a view to providing ideas for the anti-hematologic malignancies treatment and research based on the target of pyroptosis-regulated immune microenvironment.
