Progress of low-density lipoprotein receptor-related protein 1B gene in digestive system tumors
10.3760/cma.j.cn115355-20230328-00154
- VernacularTitle:低密度脂蛋白受体相关蛋白1B基因在消化系统肿瘤中的研究进展
- Author:
Pingyuan YU
1
;
Yian DU
Author Information
1. 浙江省肿瘤医院胃外科 中国科学院基础医学与肿瘤研究所，杭州 310022
- Keywords:
Low-density lipoprotein receptor-related protein 1B;
Digestive system neoplasms;
RNA interference;
Immunotherapy;
Tumor markers, biological
- From:
Cancer Research and Clinic
2023;35(10):789-793
- CountryChina
- Language:Chinese
-
Abstract:
Low-density lipoprotein receptor-related protein 1B (LRP1B) is defined as a potential cancer suppressor since it was discovered, and it has been found to be silencing in multiple tumors, and its main pathogenic mechanisms include gene mutations, epigenetic modifications in the promoter region and regulation by microRNA (miRNA). Recent studies showed that LRP1B played an important role in the occurrence and development of digestive system tumors. Combined with domestic and international research advances, this review summarizes the structure and function of LRP1B and its effect on digestive system tumors, further reveals its potential value as a marker of immunotherapy, and explores its transition from cancer inhibitor to cancer promotor in different tumors, with the aim of helping the subsequent research on the mechanism.
