Research progress of slow-release chemotherapy system for osteosarcoma
10.3781/j.issn.1000-7431.2023.2303-0118
- VernacularTitle:缓释化疗系统在骨肉瘤治疗中的研究进展
- Author:
Yisheng JING
1
;
Xingwen XIE
;
Ning LI
;
Wei XU
;
Dingpeng LI
;
Weiwei HUANG
Author Information
1. 甘肃中医药大学中医临床学院,甘肃兰州 730000
- Keywords:
Osteosarcoma;
Extended-release chemotherapy;
Drug delivery systems;
Extended-release carriers;
Smart response systems
- From:
Tumor
2023;43(12):984-992
- CountryChina
- Language:Chinese
-
Abstract:
The improvement of survival of osteosarcoma patients by the standard treatment strategy of osteosarcoma(neoadjuvant chemotherapy+surgical treatment+adjuvant chemotherapy)has been stabilized in the past 20 years,and the emergence of the slow(controlled)-release drug delivery system has provided a new strategy for the treatment of osteosarcoma.At present,thanks to the development of nanotechnology,great progress had been made to the technology of slow-release chemotherapy for osteosarcoma in China,but the clinical translation of the slow-release chemotherapy system has become the key to constrain its development.Based on this,this review summarizes the preclinical research progress of the main chemotherapeutic agents for osteosarcoma,including methotrexate,doxorubicin,cisplatin,and isocyclophosphamide,in the recent years,with the expectation of clarifying the safety and efficacy of the slow-release chemotherapy system for osteosarcoma,and facilitating the clinical translation of the slow-release chemotherapy system for osteosarcoma.
