Current status and perspectives of tumor immunotherapy efficacy evaluation methods
10.3781/j.issn.1000-7431.2023.2212-0885
- VernacularTitle:肿瘤免疫治疗疗效评价方法的现状与展望
- Author:
Yuchen GE
1
;
Baorui LIU
;
Rutian LI
Author Information
1. 南京大学医学院附属鼓楼医院肿瘤中心,南京大学临床肿瘤研究所,江苏 南京 210008
- Keywords:
Immunotherapy;
Efficacy evaluation;
Hyperprogression;
Pseudoprogression
- From:
Tumor
2023;43(9):740-746
- CountryChina
- Language:Chinese
-
Abstract:
Tumor immunotherapeutics include immune checkpoint inhibitors,adoptive cellular therapy,tumor vaccines,immunomodulators,which regulate or induce anti-tumor activity by blocking immunosuppressive signals,infusing in vitro-induced anti-tumor effector cells,and enhancing the immunogenicity of tumor cells in the fight against cancer.The effect mechanisms of tumor immunotherapy is different from that of other tumor therapeutic approaches,such as surgery and chemotherapy.Therefore,in the evaluation of anti-tumor efficacy,the use of conventional imaging methods to detect the volume change of tumor lesions shows special response patterns such as"false progression"and"superprogression",which cannot timely and accurately evaluate the objective efficacy of tumor immunotherapy.This review is an attempt to focus on those challenges in evaluating immunotherapy efficacy and the latest developments of relevant evaluation criteria,and is aimed at providing reference for the scientific evaluation of tumor immunotherapy efficacy and the selection of appropriate immunotherapy strategies for tumor patients.
