Role of exosomal proteins in detecting cancers of digestive system
10.3781/j.issn.1000-7431.2023.2209-0656
- VernacularTitle:外泌体蛋白质在消化系统恶性肿瘤中的诊断价值
- Author:
Yuxin MIN
1
;
Huangbo YUAN
;
Wenjiang DENG
;
Yanling CAI
;
Kelin XU
;
Yanfeng JIANG
;
Tiejun ZHANG
;
Xingdong CHEN
;
Chen SUO
Author Information
1. 复旦大学公共卫生学院流行病学教研室,上海 200032
- Keywords:
Exosomes;
Proteins;
Digestive system;
Neoplasms;
Diagnosis
- From:
Tumor
2023;43(8):672-683
- CountryChina
- Language:Chinese
-
Abstract:
Digestive system malignant tumor is one of the common malignant tumors in humans,and its high morbidity and low survival rate at advanced stages bring heavy disease burden to patients,families and society.However,current tumor screening technologies are not suitable for screening in large-scale populations and long-term follow-up because of the invasiveness or complexity.Thus,liquid biopsy,which based on biomarkers such as circulating tumor DNA,circulating tumor cells,exosomes and other new biomarkers,has broad prospects for development in tumor screening.Exosome,secreted by living cells,is a type of extracellular vesicle with the lipid bilayer.Compared to other biomarkers,exosome has the advantages of high stability,wide distribution,and high quantity.The various proteins carried by exosome can reflect the characteristics of the origin cells,and exosome has important research value for the early diagnosis of tumors.This article reviews the studies of exosomal proteins as biomarkers for early diagnosis of digestive system malignant tumors in the past five years,and summarizes the characteristics and limitations of the above studies,so as to provide reference for promoting the clinical transformation of exosomal proteins.
