Comparison of radiofrequency ablation and pulmonary metastasectomy in the colorectal cancer patients with lung metastases after radical resection
10.3781/j.issn.1000-7431.2023.2211-0772
- VernacularTitle:射频消融与肺转移灶切除术治疗结直肠癌根治性切除术后肺转移患者疗效的对比研究
- Author:
Zhihui FENG
1
;
Yuming FU
;
Yanwei GUO
;
Meng WANG
;
Li ZHANG
;
Jingwei XU
;
Yinghao JIANG
Author Information
1. 郑州大学第五附属医院普通外科,河南 郑州 450052
- Keywords:
Colorectal cancer;
Lung metastasectomy;
Radiofrequency ablation;
Pulmonary metastases
- From:
Tumor
2023;43(8):646-654
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To compare the clinical efficacy between radiofrequency ablation(RFA)and pulmonary metastasectomy in the colorectal cancer(CRC)patients with lung metastases after radical resection. Methods:The clinical data of 80 CRC patients with lung metastases after radical resection were analyzed retrospectively,and were divided into the surgery group(33 cases)and the RFA group(47 cases)according to the local treatment.The overall survival(OS)and progression-free survival(PFS)of the two groups were compared,as well as the prognostic factors of patients were analyzed. Results:The 3-year PFS and OS rates were 42.4％vs 31.9％and 75.8％vs 72.3％in the surgery group and the RFA group,respectively.There was no significant difference in PFS and OS between the two groups(P＞0.05).In multivariate analysis,maximum lung metastasis diameter,preoperative serum carcinoembryonic antigen(CEA)level and history of extrapulmonary metastasis were independent factors influencing OS in the CRC patients with lung metastases after radical resection(P＜0.05).In addition,preoperative serum carcinoembryonic antigen(CEA)level and history of extrapulmonary metastasis were also independent factors influencing PFS in the CRC patients with lung metastases after radical resection(P＜0.05). Conclusion:The short-term efficacy of RFA is comparable to that of pulmonary metastasectomy in the CRC patients with lung metastases after radical resection,and long-term follow-up studies are needed.
