Advancement in the research of 3D bioprinting in the treatment of liver cancer
10.3781/j.issn.1000-7431.2023.2304-0176
- VernacularTitle:3D生物打印在肝细胞癌治疗中的研究进展
- Author:
Xiaomeng XIAN
1
,
2
;
Hang SUN
;
Huayu YANG
;
Yilei MAO
Author Information
1. 北京协和医院肝脏外科,北京 100730
2. 中国医学科学院北京协和医学院,北京 100730
- Keywords:
Hepatocellular carcinoma;
3D bioprinting;
Anti-cancer drug screening;
Precision medicine;
Microfluidic printing
- From:
Tumor
2023;43(6):534-540
- CountryChina
- Language:Chinese
-
Abstract:
Hepatocellular carcinoma(HCC)is a highly lethal cancer with significant incidence and mortality rates.The study of the biological features of liver cancer cells is critical for the development of novel treatment strategies for HCC.While traditional cell culture techniques fail to provide information on the growth and diffusion of cells in a threedim-ensional space(3D),3D bioprinting technology provides a new method to study the functional characteristics of HCC cells.With the development of 3D cell culture technology,researches are largely focused on exploring the function and behavior of cells in a three-dimensional environment,particularly in complex tumor models like liver tumors that comprise intricate cellular tissues and blood vessels.This article discussed about the cellular functions that need to be studied in the 3D bioprinting environment of HCC and other tumor cells by reviewing the research progress of 3D bioprinting in HCC and various other cancer cell lines,aiming to help researchers replicate the in vivo growth environment of tumor cells more accurately,expand application scenarios,and further explore cancer treatment methods.In addition,3D bioprinting technology is considered a promising tool for drug development,providing a more clinically relevant model for the pharmacological study of anti-cancer drugs,better revealing the drug sensitivity and resistance of tumors,reducing the need for animal experiments,and providing more possibilities for precision medicine.
