Diagnosis and treatment strategy of Budd-Chiari syndrome complicated with liver cirrhosis and hepatocellular carcinoma:an analysis of 42 cases
10.3781/j.issn.1000-7431.2023.2304-0192
- VernacularTitle:巴德-基亚里综合征合并肝硬化肝细胞癌的诊治策略:42例分析
- Author:
Shengyan LIU
1
;
Luhao LI
;
Xiaowei DANG
Author Information
1. 郑州大学第一附属医院肝胆胰外科,河南省布-加综合征诊疗中心,河南 郑州 450052
- Keywords:
Budd-Chiari syndrome;
Hepatocellular carcinoma;
Prognosis
- From:
Tumor
2023;43(6):496-505
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate the diagnosis and treatment strategies as well as prognostic factors of Budd-Chiari syndrome(B-CS)patients complicated with liver cirrhosis and hepatocellular carcinoma(HCC). Methods:Clinical data of 42 B-CS patients complicated with HCC admitted to Department of Hepatopancreatobiliary Surgery,the First Affiliated Hospital of Zhengzhou University from January 2014 to December 2020 were retrospectively analyzed,and the association between the clinical characteristics of patients and whether they had undergone B-CS treatment or not before HCC diagnosis was analyzed.Kaplan-Meier method was used to plot the survival curve of the patients.COX regression model was used to analyze the risk factors affecting the prognosis of B-CS patients complicated with HCC. Results:All 42 B-CS patients complicated with HCC had liver cirrhosis,their median survival time was 28 months,and the 1-,3-and 5-year survival rates were 76.2％,50.0％and 42.9％,respectively.The maximum tumor diameter,multiple tumor ratio and total bilirubin level in patients who had not received B-CS treatment before HCC diagnosis were higher than those in patients who had.Serum albumin level(hazard ratio:0.866,95％confidence interval:0.771-0.972,P=0.015)and not receiving B-CS treatment before HCC diagnosis(hazard ratio:2.796,95％confidence interval:1.020-7.666,P=0.046)were independent risk factors for the prognosis of B-CS patients complicated with HCC. Conclusion:The prognosis of B-CS patients complicated with HCC is relatively good.Serum albumin level and not receiving B-CS treatment before HCC diagnosis are independent risk factors for the prognosis of B-CS patients complicated with HCC.
