Application of nanomaterials in tumor imaging diagnosis
10.3781/j.issn.1000-7431.2023.2305-0269
- VernacularTitle:纳米材料在肿瘤影像学诊断中的应用
- Author:
Xiaoshuai ZHANG
1
;
Hangwei FU
;
Qiping LU
Author Information
1. 中国人民解放军中部战区总医院基础医学实验室,湖北 武汉 430074
- Keywords:
Nanomaterials;
Malignant tumor;
Multimodality imaging;
Tumor targeting;
Contrast agent
- From:
Tumor
2023;43(6):478-489
- CountryChina
- Language:Chinese
-
Abstract:
Malignant tumors have become one of the major diseases that seriously endanger human life.Early diagnosis and treatment can greatly improve the survival rate of patients.Imaging examinations based on fluorescence imaging,CT,photoacoustic imaging,MRI,and PET have been widely studied and applied in the diagnosis of tumors.However,early cancerous tissue and normal tissue have similar imaging signals,which is difficult to be accurately distinguished by conventional imaging.With the development and cross integration of physics,materials science,biology,and medicine,nanomaterials have shown broad application prospects in the diagnosis and treatment of diseases due to their unique physical and chemical properties.The enhanced permeability and retention effect in solid tumor,and the easy modification properties of nanomaterials allow them to accurately"recognize"tumor and accelerate its enrichment at the tumor site;the imaging characteristics allow them to be used as contrast agents to enhance the signal intensity of the tumor site;their responsiveness mechanism can also allow them to distinguish normal from cancerous cells according to the microenvironment in tumor cells.In addition,multimodality imaging based on nanomaterials can compensate for the shortcomings of single modality imaging and achieve real-time and omnidirectional imaging of tumors.With multiple functions integrated,nanomaterials are expected to enhance the imaging signals of early cancerous sites,improve signal-to-noise ratio,and achieve early diagnosis of tumors.
