Advances in the biological function of circRNA and its research in ovarian cancer
10.3781/j.issn.1000-7431.2023.2206-0415
- VernacularTitle:circRNA生物学功能及其在卵巢癌中的研究进展
- Author:
Qing WANG
1
;
Wanlu YE
;
Yanming LU
Author Information
1. 中国医科大学附属盛京医院妇产科,辽宁 沈阳 110004
- Keywords:
Ovarian carcinoma;
Circular RNA;
Biological function;
Chemotherapy resistance;
Biomarker
- From:
Tumor
2023;43(3):229-240
- CountryChina
- Language:Chinese
-
Abstract:
Ovarian carcinoma(OC)is the most lethal malignant tumor among all gynecological tumors.Due to its low early diagnosis rate and high chemotherapy resistance,the mortality rate of OC has been high.Circular RNA(circRNA)is a kind of non-coding RNA that exists in various tissues and cells.Owing to the specific molecular structure,circRNAs are generally highly stable.In recent years,the roles of circRNAs in tumor diagnosis and treatment has become a research hotspot,including OC related circRNAs.circRNAs regulate gene expression at the transcriptional and post transcriptional level,indicating that circRNAs play an important role in the genesis and progression of tumors.Therefore,circRNAs are expected to be a potential diagnosis or prognosis marker for OC.This article will summarize the roles of circRNAs in the occurrence and development of OC and review the research progress of circRNAs in the diagnosis and treatment of OC.
