Advances in the research of m6A RNA methylation modifications in urological tumors
10.3781/j.issn.1000-7431.2023.2204-0271
- VernacularTitle:N6-甲基腺嘌呤RNA甲基化修饰在泌尿系统肿瘤中的研究进展
- Author:
Chenming GUO
1
;
Tao NIU
;
Yunfeng ZHANG
;
Dong WANG
;
Sheng GUO
;
Fenghai ZHOU
Author Information
1. 甘肃中医药大学第一临床医学院,甘肃兰州 730000
- Keywords:
urological tumors;
N6-methyladenosine;
methylation
- From:
Tumor
2023;43(3):221-228
- CountryChina
- Language:Chinese
-
Abstract:
The methylation of N6-methyladenosine(m6A)is an important gene expression regulation mechanism in eukaryotes.It is mainly regulated by three types of regulators:writers,erasers and readers.With the development of high-throughput sequencing technology and bioinformatics,various methods have been developed to detect and analyze m6A methylation sites.A growing body of research has shown that m6A methylation plays an important role in the occurrence and development of urological tumors,including tumor proliferation,invasion and metastasis.However,the molecular mechanism and role of m6A in different types of urological tumors have not been fully elucidated.This article reviews the main regulatory mechanism of m6A methylation modification as well as the research progress,the prognostic value and the therapeutic resistance of m6A methylation modification in urological tumors.
