Research progress of TAM in tumor immunotherapy
10.3781/j.issn.1000-7431.2023.2209-0609
- VernacularTitle:TAM在肿瘤免疫治疗中的研究进展
- Author:
Ye CHENG
1
,
2
;
Qingye KUAI
;
Yan ZHANG
;
Jingyun FU
;
Yu PAN
;
Tao CHEN
Author Information
1. 三峡大学健康医学院药学系,湖北 宜昌 433000
2. 国家中医药管理局中药药理(肿瘤)科研三级实验室,湖北 宜昌 433000
- Keywords:
Tumor microenvironment;
Tumor-associated macrophage;
Immune regulation;
Tumor-targeting drug
- From:
Tumor
2023;43(3):209-220
- CountryChina
- Language:Chinese
-
Abstract:
TAM(tumor-associated macrophage)is a kind of immune cell in tumor microenvironment,which mainly exists in tumor matrix to mediate inflammatory reaction.Generally,TAM can be stimulated by different cytokines to polarize into M1 macrophage or M2 macrophage with different phenotypes.In the early stage of tumor,M1 macrophages in TAM exhibit pro-inflammatory and anti-tumor activities,while as tumor progresses,TAMs tend to polarize into M2 macrophages to play anti-inflammatory and tumor-promoting roles.A large number of studies have shown that TAM is closely related to tumor growth,invasion,metastasis and poor prognosis.Therefore,targeting TAM has become the focus of anti-tumor immunotherapy.This paper has summarized the origin of TAM,and introduced the specific roles of TAM in promoting tumor proliferation,angiogenesis,migration and invasion and the formation of immunosuppressive environment.At the same time,the research progress of TAM-targeted anti-tumor immu-notherapy in recent years was discussed from 3 aspects:inhibiting monocyte recruitment,promoting TAM apoptosis and reshaping TAM phenotype.
