Progress in the application of pathogen vaccine in tumor immunotherapy
10.3781/j.issn.1000-7431.2023.2205-0361
- VernacularTitle:病原体疫苗应用于肿瘤免疫治疗的研究进展
- Author:
Hanxi ZHANG
1
;
Baorui LIU
;
Rutian LI
Author Information
1. 南京大学医学院附属鼓楼医院暨南京大学临床肿瘤学研究所,南京 210008
- Keywords:
Tumor immunotherapy;
Pathogen vaccine;
Tumor microenvironment;
Immunoregulation
- From:
Tumor
2023;43(2):122-131
- CountryChina
- Language:Chinese
-
Abstract:
Immunosuppressive tumor microenvironment is an important obstacle to tumor immunotherapy.Therefore,improving tumor microenvironment to enhance immune response is the key to improve the efficacy of immunotherapy.Based on the basic principle of immunology that the body has a strong response to"foreign"antigens and a weak response to preexisting antigens,pathogen infection can be combined with innate immune-related receptors to enhance the anti-tumor immune response.Pathogen vaccines can induce a"hot"tumor microenvironment with stronger antigen presentation and T lymphocyte activation,showing higher response to immunotherapy and having better security.In this review,we summarized the related studies on pathogen vaccine enhancing tumor immune response,including mixed bacterial vaccine,BCG vaccine,OK-432,synthetic vaccines based on tetanus toxin,modified vaccinia virus,influenza vaccine,Epstein-Barr virus and COVID-19 vaccine.The feasibility,application prospect and challenge of pathogen vaccine in tumor immunotherapy were discussed.
