Myelodysplastic syndrome:an analysis of the genetic risk factors and prognosis of 190 patients
10.3781/j.issn.1000-7431.2023.2205-0379
- VernacularTitle:骨髓增生异常综合征:190例患者的遗传学危险因素及预后分析
- Author:
Lingle HUANG
1
;
Xinyu YAN
;
Lanxiang LIU
;
Zesong YANG
;
Xin WANG
;
Xiaohua LUO
;
Hongbin ZHANG
;
Xiaoqiong TANG
;
Qing XIAO
;
Lin LIU
;
Li WANG
Author Information
1. 重庆医科大学附属第一医院血液内科,重庆 400016
- Keywords:
Myelodysplastic syndrome;
Genetic abnormality;
Prognosis analysis
- From:
Tumor
2023;43(2):83-96
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate the genetic risk factors and prognosis of 190 patients with myelodysplastic syndrome(MDS). Methods:The clinical data of 190 patients with MDS admitted to the Department of Hematology,The First Affiliated Hospital of Chongqing Medical University from January 2015 to October 2020 were analyzed retrospectively,and the genetic background and survival curve of the patients were also analyzed. Results:MDS patients with higher risk according to International Prognostic Score System(IPSS)stratification at the time of initial diagnosis had more frequent and complex types of gene mutation and chromosomal abnormalities,indicating poor prognosis.The choice of treatment is associated with the prognosis of MDS patients with intermediate risk(IPSS stratification),and the relative risk of the overall survival rate of patients treated with hypomethylating agents is higher than that of patients on concomitant medication. Conclusion:MDS patients with higher-risk(IPSS stratification)have more complex genetic risk factors and lower survival rate than those with lower-risk(IPSS stratification).MDS patients with multiple genetic risk factors have a poor prognosis,and the type of gene mutation is a predictor of prognosis.
