Research progress of long non-coding RNA in glioma
10.3781/j.issn.1000-7431.2023.2210-0692
- VernacularTitle:长非编码RNA在胶质瘤中的研究进展
- Author:
Yansong GUO
1
;
Jiang SHAO
;
Yulong WANG
;
Zhaomu ZENG
;
Yan WANG
;
Xichao WEN
;
Wensong WU
;
Kebin ZHENG
Author Information
1. 河北大学附属医院神经外科,保定 071000
- Keywords:
Glioma;
lncRNA;
Signaling pathway;
Glycolytic pathway;
Immunoregulation
- From:
Tumor
2023;43(1):70-82
- CountryChina
- Language:Chinese
-
Abstract:
Glioma is the most common type of cancer in the brain and central nervous system,mainly originated from glioma cells or neuronal cells.It is characterized by high prevalence,recurrence rate and mortality.Among aggressive brain tumors,the incidence of glioma is the highest.Long non-coding RNA(lncRNA)is one of the most popular non-coding RNAs in tumor research.It has a variety of biological functions and regulates gene expression at the transcription,post-transcription and genetic levels.It was found that lncRNA was abnormally expressed in cancer patients,and abnormally expressed lncRNA was also found in glioma.lncRNA regulates the occurrence and development of gliomas through different signaling pathways,and affects the heterogeneity and invasiveness of gliomas through the glycolytic pathway.In addition,immune-related lncRNAs are valuable in evaluating the diagnosis,treatment and prognosis of gliomas.In this article,the role of lncRNA in glioma will be reviewed from three aspects including regulation of signaling pathway,glycolytic pathway and immunoregulation.
