Observation on the Efficacy of Liangxue HuoXue Decoction with Conventional Western Medicine in the Treatment of Blood heat Psoriasis Combined with Coronary Heart Disease and the Effects on Skin Barrier Function and Blood Rheology of Patients
10.16466/j.issn1005-5509.2023.12.014
- VernacularTitle:凉血活血汤配合常规西药治疗血热型银屑病合并冠心病的疗效观察及对患者皮肤屏障功能、血液流变学的影响
- Author:
Xudong SANG
1
;
Yuanliang SHEN
;
Bibo XIE
Author Information
1. 浙江省皮肤病防治研究所 浙江,湖州 313200
- Keywords:
blood heat psoriasis;
coronary heart disease;
Liangxue Huoxue Decoction;
skin barrier function;
hemorheology;
inflammatory reaction
- From:
Journal of Zhejiang Chinese Medical University
2023;47(12):1463-1467,1475
- CountryChina
- Language:Chinese
-
Abstract:
[Objective]To investigate the efficacy of Liangxue Huoxue Decoction with conventional western medicine in the treatment of blood heat psoriasis complicated with coronary heart disease and the effects on skin barrier function and hemorheology of patients.[Methods]Eighty-eight patients with blood heat psoriasis combined with coronary heart disease from November 2019 to December 2021 were selected and randomly divided into two groups,with 44 patients in each group.The control group was treated with conventional western medicine,and the observation group was treated with Liangxue Huoxue Decoction together with conventional western medicine.The clinical efficacy,adverse reactions,as well as skin barrier function,hemorheological indicators,serum inflammatory factors interleukin-1(IL-1),IL-6,IL-8,and tumor necrosis factor-α(TNF-α),lesion area and severity index(PASI),and Barthel index(BI)were compared before and after treatment between the two groups.[Results]Compared with control group(70.45％),the total effective rate of treatment in observation group(88.64％)was higher(P＜0.05),and there was no statistically significant difference in the incidence of adverse reactions between observation group and control group(P＞0.05).After 2 weeks and 4 weeks of treatment,the stratum corneum water content and sebum content in observation group were higher than control group and the transepidermal water loss,whole blood high cut and low cut viscosity,erythrocyte specific volume,plasma viscosity and IL-1,IL-6,IL-8 and TNF-α level were lower than control group(P＜0.05).After 4 weeks and 12 weeks of treatment,the PASI score was lower and the BI was higher in observation group than control group(P＜0.05).[Conclusion]Liangxue Huoxue Decoction together with conventional western medicine can effectively reduce the inflammatory response of the body and improve the skin barrier function and hemorheological indicators in the treatment of patients with psoriasis combined with coronary heart disease,with good effect and high safety.
