Efficacy of gold microneedle combined with tranexamic acid transdermal administration for treatment of post-inflammatory hyperpigmentation from acne vulgaris
10.3760/cma.j.issn.1671-0290.2024.01.004
- VernacularTitle:黄金微针结合氨甲环酸透皮给药治疗痤疮炎症后色素沉着的效果
- Author:
Zhen LI
1
;
Yinyin SHI
;
Jiangying HOU
;
Hong CAI
Author Information
1. 北京空军特色医学中心皮肤激光医学中心，北京 100142
- Keywords:
Acne vulgaris;
Therapeutic alliance;
Post-inflammatory hyperpigmentation;
Gold microneedle;
Tranexamic acid
- From:
Chinese Journal of Medical Aesthetics and Cosmetology
2024;30(1):19-23
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To evaluate the efficacy of gold microneedle combined with tranexamic acid transdermal administration for the treatment of post-inflammatory hyperpigmentation caused by acne vulgaris.Methods:From January 2022 to October 2022, 36 patients with post-inflammatory hyperpigmentation of facial acne who went to the Laser Medical Center, Air Force Medical Center were treated, including 10 males and 26 females, with 21-42 (28.3±4.8) years of age. The patients were divided into observation group and control group, with 18 cases in each group. The observation group was treated with gold microneedle combined with transdermal administration of tranexamic acid, the control group with 0.5 mm microneedles combined with transdermal administration of tranexamic acid. Both groups were treated for 2 times with an interval of 2 months. The total effective rate, post acne hyperpigmentation index (PAHPI), UV spots, brown spots, pores, skin texture, and adverse reaction were evaluated at 4 weeks after the last treatment.Results:Clinical observation was completed in all 36 patients. In the observation group, 17 cases were effective, accounting for 94.4%, and in the control group, 11 cases were effective, accounting for 61.1%, The curative effect of the observation group was better than that of the control group, and the difference between the two groups was statistically significant ( P<0.05). The differences in PAHPI score, UV spots, brown spots, pores, and skin texture between the two groups were also statistically significant ( t=3.10, 2.52, 2.71, 2.43 and 3.54; P=0.004, 0.017, 0.001, 0.021 and 0.001). The patiens in both groups had different degrees of burning sensation, erythema, edema. dryness and other symptoms after treatment, which were relieved 3 days after treatment without special treatmet. Conclusions:Gold microneedle plus transdermal administrationof tranexamic acid is a safe and effective method for the treatment of post-inflammatory pigmentation caused by acne vulgaris.
