Research progress on pathogenicity and related virulence factors of Klebsiella oxytoca

VernacularTitle:产酸克雷伯菌致病性及相关毒力因子研究进展
Author: Yun WU ¹ ; Ruirui MA ; Yingchun XU ; Yali LIU
Author Information

1. 中国医学科学院北京协和医院研究生院，北京　100730
Keywords: Klebsiella oxytoca; Antibiotic-associated hemorrhagic colitis; Cytotoxins; pathogenicity; Virulence factors
From: Chinese Journal of Laboratory Medicine 2024;47(4):460-466
CountryChina
Language:Chinese
Abstract: Klebsiella oxytoca is an important opportunistic pathogen which cause community or hospital-acquired infections in adults and children. The disease it most causes is antibiotic-associated hemorrhagic colitis (AAHC). It can also cause diseases such as urinary tract infections, pneumonia and bloodstream infections. The cytotoxins including Tilivalline and Tilimycin are important virulence factors for Klebsiella oxytoca, mainly causing AAHC. This article reviewed the progress of research on the prevalence, pathogenicity and mechanisms of K.oxytoca, hoping to improve the understanding of K.oxytoca and provide guidance on disease prevention and treatment.