Research progress of DNA methylation in the diagnosis and treatment of nasopharyngeal carcinoma
10.3760/cma.j.cn114452-20231113-00276
- VernacularTitle:DNA甲基化在鼻咽癌诊疗中的研究进展
- Author:
Zhiwei ZHOU
1
;
Tai QIAN
;
Qiongxia ZHANG
;
Dingsheng WEN
;
Yuli LIU
;
Honghao ZHOU
Author Information
1. 广东药科大学附属第一医院临床药学重点专科，广州 510080
- Keywords:
Nasopharyngeal neoplasms;
DNA methylation;
Biological markers;
Diagnostic services
- From:
Chinese Journal of Laboratory Medicine
2024;47(4):455-459
- CountryChina
- Language:Chinese
-
Abstract:
Nasopharyngeal carcinoma is a common malignant tumor in southern China, and its occurrence and development mechanism are still not fully understood. However, a large number of studies have shown that DNA methylation has important clinical application value in the screening, diagnosis, treatment and prognosis evaluation of nasopharyngeal carcinoma. DNA methylation affects the division cycle, growth, invasion and migration of nasopharyngeal carcinoma cells by regulating the transcription and protein expression levels of genes associated with tumorigenesis and development. In addition, there are significant differences in DNA methylation expression levels in different stages of nasopharyngeal carcinoma, which provides theoretical guidance and clinical reference for the early diagnosis, timely treatment and response evaluation of nasopharyngeal carcinoma. Current studies have shown that DNA methylation detection may provide a simple and efficient early screening method for nasopharyngeal carcinoma, and can also explore new ideas for the development of non-invasive screening methods.
