Advances in therapeutic drug monitoring methods based on liquid chromatography-tandem mass spectrometry
10.3760/cma.j.cn114452-20230915-00144
- VernacularTitle:基于液相色谱-串联质谱技术的治疗药物监测方法研究进展
- Author:
Ziying LI
1
;
Jie XIE
;
Ziyu QU
;
You JIANG
;
Di ZHANG
;
Songlin YU
;
Xiaoli MA
;
Ling QIU
;
Xinhua DAI
;
Xiang FANG
;
Xiaoping YU
Author Information
1. 中国计量大学生命科学学院，检验检疫研究所，杭州 310018
- Keywords:
Chromatography, liquid;
Tandem mass spectrometry;
Therapeutic drug monitoring;
Sample pretreatment;
Challenge
- From:
Chinese Journal of Laboratory Medicine
2024;47(3):332-340
- CountryChina
- Language:Chinese
-
Abstract:
Liquid chromatography-tandem mass spectrometry (LC-MS/MS) technology has the characteristics of high specificity and high throughput, making it rapidly applied and developed in the field of clinical testing. Its application in the monitoring of therapeutic drugs can effectively improve the quantitative accuracy and sensitivity, and formulate a personalized and optimal dosing plan for patients. However, this technology still faces some challenges, and automation, quality control, and quantitative traceability will be the future development direction.
