Development of clinical mass spectrometry laboratories: opportunities and challenges
10.3760/cma.j.cn114452-20240111-00021
- VernacularTitle:临床质谱实验室发展中的机遇与挑战
- Author:
Ling QIU
1
;
Jun ZHANG
;
Zhou ZHOU
;
Weiyan ZHOU
;
Huafen LIU
;
Xiaoli MA
;
Baishen PAN
Author Information
1. 中国医学科学院 北京协和医院检验科，北京 100730
- Keywords:
Mass spectrometry;
Clinical laboratory techniques
- From:
Chinese Journal of Laboratory Medicine
2024;47(3):216-223
- CountryChina
- Language:Chinese
-
Abstract:
Clinical application of mass spectrometry technology has attracted the attention of clinical laboratory experts due to its high sensitivity, high specificity, and capacities of simultaneous detection of multiple compounds. In recent years, mass spectrometry technology has made significant achievements in the fields of identification of pathogenic microorganism, detection of trace elements and heavy metals, small molecule hormones, vitamins, amino acids, peptides and proteins, as well as therapeutic drug monitoring (TDM) and poisoning drugs screening. In order to further clarify the opportunities and challenges brought by this complex mass spectrometry technology in the field of clinical laboratory, the Chinese Journal of Laboratory Medicine invited experts and scholars of laboratory medicine to share their experience and opinions on related items focusing on the positioning of mass spectrometry technology in the clinical laboratory, the development and improvement of the clinical laboratory by mass spectrometry technology, the challenges of interpreting mass spectrometry test results, the challenges of operating and managing clinical mass spectrometry laboratories, and ways of improving the application of clinical mass spectrometry laboratories with this technology. Agreement was achieved in that the introduction of mass spectrometry technology into the clinical laboratory could bring new directions and opportunities for clinical testing and research, and also is associated with a series of challenges such as the difficulty of sample pretreatment, the high cost and complexity of mass spectrometry technology, the complexity of data processing and interpretation, the lack of standards and norms, and the issue of determining the price of mass spectrometry examinations.
