Application and research progress of cell-free DNA in the diagnosis and treatment of related disease
10.3760/cma.j.cn114452-20230729-00032
- VernacularTitle:游离DNA检测技术及其在疾病诊疗中的应用和研究进展
- Author:
Xinyi LU
1
;
Qingtai MENG
;
Ping HUANG
;
Yagan DUAN
;
Zhiyuan CHEN
;
Peng XU
;
Fengmin ZHANG
Author Information
1. 哈尔滨医科大学医学微生物学教研室，伍连德研究所，黑龙江省免疫与感染重点实验室，黑龙江省普通高校病原生物学重点实验室，哈尔滨 150081
- Keywords:
Gene test;
Sequencing;
Cancer;
Prenatal examination;
Autoimmune disease
- From:
Chinese Journal of Laboratory Medicine
2024;47(2):197-204
- CountryChina
- Language:Chinese
-
Abstract:
Cell-free DNA (cfDNA) is the DNA fragment existing in human extracellular fluid. In specific physiological process (such as pregnancy) or pathological conditions (such as human malignancies), the contents of cfDNA in extracellular fluid will abnormally change. The contents and molecular characteristics of cfDNA make it have the potential as a kind of biomarker for diseases′ diagnosis. With the development of cfDNA detection technology such as sequencing and mass spectrometry, liquid biopsy based on cfDNA detection has been widely used in clinical tumor diagnosis, tumor treatment, prenatal examination, and research in autoimmune diseases. A systematic summary of the latest research progress in the development of cfDNA detection technology and the clinical application of liquid biopsy, as well as the research progress of cfDNA in the diagnosis and treatment of related diseases is summarized in this review.
