Clinical application of exosomes in common neurodegenerative diseases
10.3760/cma.j.cn114452-20231014-00211
- VernacularTitle:外泌体在常见神经退行性疾病中的临床应用
- Author:
Bingxing CHEN
1
;
Chao WANG
;
Xiuru GUAN
Author Information
1. 哈尔滨医科大学附属第一医院检验科，哈尔滨150000
- Keywords:
Neurodegenerative diseases;
Biomarker;
Early diagnosis;
Treatment monitoring;
Exosome
- From:
Chinese Journal of Laboratory Medicine
2024;47(2):122-128
- CountryChina
- Language:Chinese
-
Abstract:
Exosomes are nanoscale extracellular vesicle structures that communicate and exchange information between cells. They carry a variety of biologically active molecules whose compositions and contents vary according to the origin and recipient cells. Therefore, exosomes can be used as biomarkers. Neurodegenerative diseases are diseases with hidden onset, so early screening and accurate diagnosis is undoubtedly a reliable guarantee to reduce their mortality and increase the cure rate. Exosomes, as a research hotspot in recent years, have great potential for the diagnosis and treatment of diseases given their transport capacity and contents, and have significant advantages in abundance, stability, diversity and accessibility. The purpose of this paper is to discuss exosomes as potential candidates for early diagnosis of neurodegenerative diseases, and thus to elaborate new fields of their application, with a view to providing a richer perspective for clinical prediction and treatment.
