Prospects for the application of blood-based biomarkers in Alzheimer′s disease
10.3760/cma.j.cn114452-20231018-00220
- VernacularTitle:阿尔茨海默病血液生物标志物的应用前景
- Author:
Huimin CAI
1
;
Longfei JIA
Author Information
1. 首都医科大学宣武医院神经疾病高创中心 神经内科，北京 100053
- Keywords:
Alzheimer disease;
Biomarker;
Amyloid β-protein
- From:
Chinese Journal of Laboratory Medicine
2024;47(2):116-121
- CountryChina
- Language:Chinese
-
Abstract:
The early diagnosis of Alzheimer′s disease (AD) has long been a challenge in the field of medicine. In recent years, research on blood biomarkers of AD has flourished, which holds significant promise for advancing the early diagnosis, monitoring, and early intervention of AD. With the new generation of ultra-sensitive detection techniques, a series of studies have successfully validated core biomarkers, non-specific biomarkers, and other relevant biomarkers of AD in blood. However, the use of blood-based biomarkers for the diagnosis and prediction of AD still faces some challenges related to accuracy and robustness. This article compiles and analyzes the advances, strengths, and limitations of each type of biomarkers, and provides several potential strategies to address these challenges.
