The application of collagen-related biomarkers in heart failure
10.3760/cma.j.cn114452-20230816-00060
- VernacularTitle:胶原相关生物标志物在心力衰竭中的应用
- Author:
Jiashu YANG
1
;
Hui YUAN
Author Information
1. 首都医科大学附属北京安贞医院检验科，北京 100029
- Keywords:
Collagen;
Biomarkers;
Heart failure;
Myocardial fibrosis
- From:
Chinese Journal of Laboratory Medicine
2023;46(12):1318-1323
- CountryChina
- Language:Chinese
-
Abstract:
Myocardial remodeling is one of the major pathogenic mechanisms in chronic heart failure, and myocardial fibrosis plays an important role in myocardial remodeling. Myocardial fibrosis is mainly due to the synthesis exceeding degradation of collagen, resulting in the accumulation of collagen. The metabolites produced during the dynamic transformation of collagen synthesis and degradation can indirectly reflect myocardial fibrosis. Due to the complexity of collagen metabolism and the large number of intermediate products, it has not been widely used as a biomarker in clinical practice. We briefly reviewed the process of collagen metabolism and its products, and focused on the clinical value of collagen metabolites (PICP, PIIINP, and MMP) in the diagnosis, risk stratification, and prognostic assessment of heart failure. It provides a reference basis for the wide application of collagen-related biomarkers in heart failure in the future.
