Application of metagenomic next-generation sequencing in Streptococcus suis infection: a case report
10.3760/cma.j.cn114452-20230117-00033
- VernacularTitle:宏基因组高通量测序在猪链球菌感染中的应用1例
- Author:
Tingting SHEN
1
;
Xiaofeng LIU
;
Dongmiao CHEN
;
Duoduo LIU
Author Information
1. 南方医科大学南方医院检验科，广州 510515
- Keywords:
Streptococcus suis;
Infection;
Metagenomic next-generation sequencing
- From:
Chinese Journal of Laboratory Medicine
2023;46(9):955-957
- CountryChina
- Language:Chinese
-
Abstract:
A case of Streptococcus suis sepsis and streptococcal toxic shock syndrome diagnosed by metagenomic next-generation sequencing (mNGS) was presented. A 50-year old male patient visited Zengcheng Branch of Nanfang Hospital on June 25th, 2021. The patient developed fever, dizziness and shock with typical epidemiological history. mNGS revealed Streptococcus suis in blood sample. The diagnosis of Streptococcus suis sepsis and streptococcal toxic shock syndrome were made. Meropenem was given as empirical antibiotics. Antibiotics were adjusted to meropenem and clindamycin while Streptococcus suis was detecting by mNGS and downgraded to piperacillin/tazobactam and clindamycin when symptoms improved. The diagnosis was then confirmed by blood culture. The patient developed dry gangrene and sudden deafness in the later stage and was discharged after treatment. Compared with traditional diagnostic techniques, mNGS has advantages such as timeliness and accuracy, and plays a key role in the field of severe infections and rare pathogen infections. It is suggested that combining mNGS and traditional diagnostic techniques have the advantages for early diagnosis and early treatment.
