Application of high-throughput sequencing in precision medicine of tumor
10.3760/cma.j.cn114452-20230301-00029
- VernacularTitle:高通量测序技术在肿瘤精准诊疗中的临床应用
- Author:
Yuanling JIANG
1
;
Nengtai OUYANG
Author Information
1. 中山大学孙逸仙纪念医院细胞分子诊断中心，广州 510000
- Keywords:
Next-generation sequencing;
Genetic test;
Targeted therapy
- From:
Chinese Journal of Laboratory Medicine
2023;46(9):893-898
- CountryChina
- Language:Chinese
-
Abstract:
The high-throughput sequencing (NGS) method has been widely used in clinical diagnosis and treatment due to its ability to simultaneously analyze multiple samples, genes and variation types with a single test when compared to some traditional methods. In addition to providing important information for clinical diagnosis and treatment, a large amount of information with clinical research value can be digged. On the other hand, further basic research and targeted therapy promoted a new way of treating cancer patients, which is currently named as precision medicine (PM). In cancer care, this means custom treatments to each patient′s features and each cancer genomic alterations. With this conception, the use of NGS and the consequent availability of large-scale human genome databases have created an opportunity for significant onward movement of cancer diagnosis and therapy. We here discuss the applications of NGS in cancer care, under a"personalized tailored therapy"perspective.
