Research progress on the bidirectional effect of autophagy on retinal neurovascular unit cells in diabetic retinopathy
10.3760/cma.j.cn511434-20230512-00213
- VernacularTitle:自噬对糖尿病视网膜病变的神经血管单元组成细胞双向作用的研究进展
- Author:
Jiayuan ZHUANG
1
;
Xiangxia LUO
;
Wanrui ZHENG
;
Xiaohua MA
Author Information
1. 甘肃中医药大学中医临床学院，兰州 750000
- Keywords:
Diabetic retinopathy;
Neurovascular unit;
Autophagy;
Bidirectional action;
Review
- From:
Chinese Journal of Ocular Fundus Diseases
2024;40(2):159-164
- CountryChina
- Language:Chinese
-
Abstract:
Diabetes retinopathy (DR) is a blinding ocular complication of diabetes, and its pathological mechanism is complex. The damage to the retinal neurovascular unit (NVU) and the imbalance of its coupling mechanism are important pathological foundations. Autophagy plays an important role in the progression of DR. Oxidative stress, endoplasmic reticulum stress, hypoxia, and competitive endogenous RNA regulatory networks can affect the occurrence of autophagy, and autophagy induced cell death is crucial in NVU dysfunction. Retinal neurocyte are non-renewable cells, and adaptive autophagy targeting neuronal cells may provide a new direction for early vision rescue in patients with DR. It is necessary that exploring the possible autophagy interrelationships between ganglion cells, glial cells, and vascular constituent cells, searching for targeted specific cell autophagy inhibitors or activators, and exploring the impact of autophagy on the NVU complex more comprehensively at the overall level. Adopting different autophagy intervention methods at different stages of DR may be one promising research directions for future DR.
