Elevated blood pressure increases risk of proliferative diabetic retinopathy: a Mendelian randomization study
10.3760/cma.j.cn511434-20230707-00301
- VernacularTitle:血压升高增加增生型糖尿病视网膜病变发生风险的孟德尔随机化分析
- Author:
Gang SU
1
;
Zhao LIU
;
Shanjun CAI
Author Information
1. 遵义医科大学附属医院眼科 贵州省眼科医院 国家眼病临床研究中心贵州省分中心 贵州省眼疾病特色重点实验室，遵义 563003
- Keywords:
Mendelian randomization;
Systolic blood pressure;
Diastolic blood pressure;
Proliferative diabetic retinopathy
- From:
Chinese Journal of Ocular Fundus Diseases
2024;40(2):142-147
- CountryChina
- Language:Chinese
-
Abstract:
Objective:Mendelian randomization (MR) was used to analyze the potential relationship between blood pressure and proliferative diabetic retinopathy (PDR).Methods:Two-sample MR analysis was performed using summary statistics from genome-wide association studies. Systolic blood pressure (SBP) and diastolic blood pressure (DBP) were selected as the exposure, PDR as the outcome. The instrumental variable of SBP and DBP came from the publicly available data of the the UK Medical Research Council Comprehensive Epidemiology Unit and Neale Laboratory; the outcome data (8 681 cases in the case group, 204 208 cases in the control group, European population) are from the FinnGen database. Inverse variance weighting (IVW) and weighted median (WM) were used to analyze the potential relationships between SBP, DBP and PDR.Results:MR analysis showed that IVW [SBP: odds ratio ( OR)=1.36, 95% confidence interval ( CI) 1.17-1.57, P= 4.22E-05; DBP: OR=1.29, 95% CI 1.11-1.51, P=8.6E-04], WM (SBP: OR=1.33, 95% CI 1.07-1.66, P=0.009; DBP: OR=1.28, 95% CI=1.03-1.59, P=0.002). The results showed that elevated SBP and DBP increased the risk of PDR. Conclusion:Blood pressure (SBP, DBP) change is positively correlated with the risk of PDR.
