The status and progress of gene therapy delivery techniques for retinal diseases
10.3760/cma.j.cn511434-20220803-00435
- VernacularTitle:视网膜疾病基因治疗递送方式的研究现状与进展
- Author:
Licong LIANG
1
;
Kaiqin SHE
;
Fang LU
Author Information
1. 四川大学华西医院眼科，成都 610041
- Keywords:
Retinal diseases;
Gene therapy;
Gene delivery;
Subretinal injection;
Intravitreal injection;
Suprachoroidal injection;
Review
- From:
Chinese Journal of Ocular Fundus Diseases
2024;40(1):67-75
- CountryChina
- Language:Chinese
-
Abstract:
Gene therapy is designed to introduce genetic material into the cells of a patient via virus to enhance, inhibit, edit or add a genetic sequence, results in a therapeutic or prophylactic effect. Gene therapy has brought positive influence and great potential for the treatment of retinal diseases including genetic retinal diseases and acquired retinal diseases. In addition to the constant optimization of gene vectors, the exploration of different drug delivery techniques has brought different therapeutic effects for gene therapy of retinal diseases. The main delivery methods include subretinal injection, intravitreal injection, suprachoroidal injection. Considering the transfection efficiency and safety of delivery methods, emerging sub-inner limiting membrane injection and noninvasive gene delivery are under investigation. The selection of gene delivery method is very important for the safety and effectiveness of gene therapy for retinal diseases. It is not only related to the development of equipment and technology, but also related to the modification of adeno-associated virus, the selection of promoter and the specific retinal cells that the target gene wants to be transfected. Therefore, the most appropriate method of gene delivery should be selected according to the final gene therapy agent and the specific transfected cells after taking all these factors into consideration.
