Recent advances in nonhuman primate models of macular diseases
10.3760/cma.j.cn511434-20221207-00647
- VernacularTitle:非人灵长类动物黄斑疾病模型的研究进展
- Author:
Hailong HE
1
;
Zibing JIN
Author Information
1. 北京市眼科研究所 北京同仁眼科中心 首都医科大学附属北京同仁医院 北京市眼科学与视觉科学重点实验室，北京 100005
- Keywords:
Nonhuman primate;
Animal model;
Macular diseases;
Review
- From:
Chinese Journal of Ocular Fundus Diseases
2023;39(11):953-958
- CountryChina
- Language:Chinese
-
Abstract:
The macula is a critical anatomical structure for primates to acquire high-resolution spatial and color vision, with macula lesions posing a significant threat to patients' visual function and quality of life. Non-human primate (NHP) are the only mammals with a macular structure that is closest to that of humans, thus offering substantial value in the study of macular diseases. Currently, various methods, including spontaneous occurrence, gene editing, drug-induced, light-induced, and mechanical injury, can be employed to screen and establish NHP models for investigating conditions such as oculocutaneous albinism, achromatopsia, retinitis pigmentosa, age-related macular degeneration, and certain rare ocular syndromes. When constructing NHP models, due consideration should be given to other animal models to facilitate complementary research across different model systems. Additionally, leveraging the advantages of NHP and establishing genetically controlled NHP strains is a goal to strive for to achieve sustainable utilization of these resources in research.
